Abstract
A series of urea compounds based on the tripeptide Phe-Trp-Lys were synthesized and pharmacologically characterized at the mouse melanocortin receptors. The results include identification of novel melanocortin receptor agonists with potencies ranging from nanomolar to micromolar.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Mice
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Oligopeptides / chemistry
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Oligopeptides / pharmacology
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Receptors, Melanocortin / agonists*
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Structure-Activity Relationship
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Urea / analogs & derivatives*
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Urea / chemical synthesis
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Urea / pharmacology*
Substances
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Oligopeptides
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Receptors, Melanocortin
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Urea